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. 2006 Jul;50(7):2516–2521. doi: 10.1128/AAC.01226-05

FIG. 1.

FIG. 1.

(Top) Ribbon representation of the class A β-lactamase from Mycobacterium fortuitum. The active-site serine (S) is indicated by a black sphere. (Bottom) Sequence alignment of class A β-lactamases from M. fortuitum (accession no. uniprot Q59517), M. tuberculosis H37Rv (P0A516), S. albus G (P14559), E. coli Toho-1 (Q47066), P. vulgaris K1 (P52664), Y. enterocolitica (Q01166), and E. coli TEM-1 (Q4AE67). The four conserved motifs of class A β-lactamases are boxed. Blue, strictly conserved residues; yellow, active-site conserved residues; green, Arg 220, 244, or 276 (278); orange, other residues discussed in the text.