FIG. 2.

Dose-response curves showing the effects of compounds 13b (upper panel) and 13e (lower panel) on macrophage survival and macrophage infection rate in the absence or presence of IFN-γ. Macrophages were infected with stationary-phase L. major promastigotes for 24 h. After removal of extracellular parasites, the cells were incubated further for 48 h in the absence of drugs, or in the presence of increasing concentrations of compounds with or without IFN-γ (100 U ml⁻¹). The arrows point out normalized survival and infection rates of macrophages incubated without drugs, i.e., in the absence or presence of IFN-γ alone.