TABLE 2.
Excretion in human urine and feces
| Property, analyte, or ratio | Parameter (unit) | Value in urine (mean ± SD) (n = 6) | Value in feces (mean ± SD) (n = 6) | Total value (mean ± SD) (n = 6) |
|---|---|---|---|---|
| Radioactivity (A) | fe (% of dose) | 50.8 ± 14.0 | 26.1 ± 13.8 | 76.9 ± 5.46 |
| CLR (ml/min) | 114 ± 14.6 | NAa | NA | |
| CL/F (ml/min) | 227 ± 80.0 | NA | NA | |
| Viramidine (B) | fe (% of dose) | 3.39 ± 0.682 | NA | NA |
| CLR (ml/min) | 172 ± 24.3 | NA | NA | |
| CL/F (ml/min) | 4610 ± 1530 | NA | NA | |
| Ribavirin (C) | fe (% of dose) | 10.0 ± 0.965 | NA | NA |
| CLR (ml/min) | 67.6 ± 3.90 | NA | NA | |
| CL/F (ml/min) | NA | NA | NA | |
| B/A | fe | 0.0667 | NA | NA |
| C/A | fe | 0.197 | NA | NA |
| B/C | fe | 0.339 | NA | NA |
a
NA, not applicable.