FIG. 1.

Profiles of time versus fosfomycin concentration in plasma and fluid in interstitial space in noninflamed and inflamed subcutaneous soft tissue in patients with cellulitis (a) or diabetic foot infection (b). Patients with severe uncomplicated cellulitis of lower extremities were given 68 ± 4.9 mg of fosfomycin per kg of body weight, and patients with diabetic foot infection were given 67.8 ± 4.9 mg/kg of body weight. Fosfomycin was infused i.v. for 30 min starting at time zero (t = 0 min). Results are given as means ± SEMs (six patients in each group).