Functional complementation of glo3Δ gcs1Δ mutant in yeast by RPA. A, glo3Δ gcs1Δ mutant cell transformed with RPA and the GCS1 positive control could grow at 37°C, whereas the cells transformed with GCS112 (12 amino acids) could not grow. The PPY147.28.2A cells containing a temperature-sensitive GCS1 allele also could not grow at 37°C. B, All yeast cells could grow at the permissive temperature 23°C. C, Schematic drawing depicts the position of yeast cells transformed with genes as indicated. RPA, RPA gene; RPArecovery, RPA plasmid was reisolated from single yeast colony and retransformed into the mutant; GCS1, GCS1 gene; GCS112, GCS1 fragment containing 12 amino acids from the N terminus; PPY147.28.2A, control cells not transformed.