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Effect of thrombin on the release of IL-8 from A549 cells. Cells were incubated (A) with various concentrations of thrombin at 37°C for 16 h, or (B) with 10 U/ml of thrombin for 2 h, 8 h and 16 h. Values shown are mean ± SE for 5 separate experiments. *P < 0.05 compared with the response to medium alone control.
