TABLE 7.
Effects of 7-substituted 9-aminomethoxyacridines and related bis- and tetra-acridines on Leishmania biochemical pathways
| Compound | Effect at the IC50 (% compared to control culture) on:
|
|||||
|---|---|---|---|---|---|---|
| S + G2M phase | Protein content | Membrane potential | Polar lipids | Neutral lipids | Mitochondrial potential | |
| A2 | 76.9 | 78.2 | 100.3 | 152.3 | 114.2 | 99.9 |
| A3 | 80.2 | 77.4 | 99.2 | 98.4 | 99.5 | 100.1 |
| A4 | 84.5 | 82.6 | 100.4 | 102.5 | 100.4 | 98.9 |
| A48 | 96.2 | 82.9 | 100.1 | 128.6 | 105.8 | 95.8 |
| A66 | 78.6 | 83.8 | 99.3 | 62.1 | 85.3 | 100.2 |
| A65 | 86.5 | 80.3 | 100.1 | 99.8 | 100.2 | 100.4 |
| A57 | 79.7 | 86.5 | 98.2 | 96.5 | 100.4 | 99.6 |
| A64 | 77.5 | 94.1 | 99.1 | 80.2 | 92.1 | 93.5 |
| A55 | 95.2 | 100.1 | 100.1 | 97.6 | 95.4 | 98.4 |
| A62 | 81.4 | 77.3 | 99.7 | 99.1 | 96.3 | 100.4 |
| B28 | 85.2 | 76.7 | 99.7 | 155.2 | 113.4 | 101.1 |
| B16 | 75.3 | 72.8 | 96.4 | 115.3 | 106.4 | 97.6 |
| B29 | 81.8 | 84.7 | 98.6 | 194.2 | 124.6 | 98.4 |
| C19 | 83.4 | 73.3 | 100.1 | 98.8 | 100.2 | 102.3 |
| C20 | 77.1 | 92.2 | 99.9 | 100.1 | 99.1 | 96.3 |
| C14 | 87.1 | 63.5 | 99.3 | 105.5 | 98.6 | 98.6 |
| C15 | 84.3 | 76.1 | 98.6 | 99.5 | 100.3 | 101.2 |
| Pentamidine | 58.6 | |||||
| Allopurinol | 51.1 | |||||
| Amphotericin B | 55.2 | |||||
| Ketoconazole | 71.3 | 92.4 | ||||
| FCCP | 10.2 | |||||