TABLE 1.
In vitro antibacterial activities of RWJ-54428 and other drugs against strains used in animal models
| Antibiotic | MIC (μg/ml)
|
|||||
|---|---|---|---|---|---|---|
| MSSA Smith | MRSA COL | MRSA 076 | VISA HIP-5836 | S. pneumoniae ATCC 6301 | E. faecalis ATCC 23241 | |
| RWJ-54428 | 0.125 | 1 | 1 | 0.5 | 0.015 | 0.125 |
| Ampicillin | NDa | 16 | >32 | ND | ND | 2 |
| Cefazolin | 0.25 | >32 | >32 | ND | ND | ND |
| Cefotaxime | 2 | >32 | >32 | 8 | 0.015 | ND |
| Imipenem | 0.03 | 32 | 64 | 2 | ND | 1 |
| Penicillin G | 0.125 | 8 | 64 | ND | 0.06 | ND |
| Q-Db | ND | 0.06 | 0.25 | 0.25 | ND | 4 |
| Vancomycin | 1 | 1 | 0.5 | 8 | 0.25 | 1 |
a
ND, not determined.
b
Q-D, quinupristin-dalfopristin.