TABLE 4.
In vivo antibacterial activities of RWJ-54428, ampicillin, and vancomycin in a mouse model of pyelonephritis caused by E. faecalis ATCC 23241a
| Compound | MIC (μg/ml) | Total daily doseb (mg/kg) | Mean ± SD log CFU in kidneysc |
|---|---|---|---|
| No treatment | 0 | 6.8 ± 0.8 | |
| RWJ-54428 | 0.125 | 3 | 6.8 ± 0.4 |
| 30 | 5.9 ± 0.3* | ||
| 90 | 4.8 ± 0.3** | ||
| Ampicillin | 2 | 30 | 6.4 ± 0.8 |
| 150 | 6.3 ± 0.4 | ||
| 300 | 4.6 ± 1.2** | ||
| Vancomycin | 1 | 30 | 6.1 ± 0.3 |
| 90 | 5.6 ± 0.4* | ||
| 180 | 5.3 ± 0.4** |
a
The challenge dose was 1.2 × 108 CFU/mouse.
b
Doses were administered three times daily for 3 days, starting 24 h postinoculation.
c
The numbers of viable CFU in kidneys harvested 16 to 20 h after the last dose. The difference between the control and each treated group was determined by using a Peritz F test (∗, P < 0.05; ∗∗, P < 0.01).