TABLE 6.

In vivo activities of RWJ-54428, imipenem, and vancomycin in a neutropenic mouse thigh model caused by MRSA COL

Compound	MIC (μg/ml)	Dose (mg/kg)	Max Δ log CFU/thigha	ERTb (h)	In vivo PAE (h)
No treatment		0	2.7	NAc	NA
RWJ-54428	1	1	−0.3	4.4	NDd
		10	−0.5	5	2.3
		30	−0.6	8	6.5
Imipenem	32	30	0.6	0	0
Vancomycin	1	20	−0.5	8	18
		30	−0.7	16	>20

^aMax Δ log CFU/thigh, maximum reduction in bacterial counts compared to those for the controls at the start of therapy.

^bERT, effective regrowth time.

^cNA, not available.

^dND, not determined.