FIG. 1.

(a) Time-kill graph for an isolate of M. pneumoniae (MIC, 0.032 μg/ml) against which the activities of garenoxacin at concentrations one to eight times the MIC were tested. Bactericidal effects were demonstrated at eight times the MIC after 24 h of incubation; at two, four, and eight times the MIC after 48 h of incubation; and at all concentrations after 96 h of incubation. Regrowth of ≤2 log₁₀ CFU was observed in the presence of some of the lower concentrations of antimicrobials after 120 and 144 h of incubation. (b) Time-kill graph for an isolate of M. hominis (MIC, 0.008 μg/ml) against which the activities of garenoxacin at concentrations one to eight times the MIC were tested. Bactericidal effects were demonstrated at four and eight times the MIC after 24 h of incubation; and bactericidal effects were demonstrated at two, four, and eight times the MIC after 48 h of incubation. Regrowth of 1 log₁₀ CFU was observed after 48 h of incubation at the concentration equal to the MIC.