Table 1.
Diagnostic Efficacy of the Posttreatment Value of Urea Breath Test to Predict the Clarithromycin Resistance of H. pylori After Failed Triple Therapy and Before Treatment
| Cutoff Point of Urea Breath Test | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) |
|---|---|---|---|---|
| After failed triple therapy | ||||
| >10 | 94.2 (84.6 to 100) | 50 (39.2 to 61.8) | 78.6 (66.2 to 91.4) | 81.8 (54.4 to 100) |
| >15 | 88.6 (78.1 to 99.1) | 88.9 (71 to 100) | 93.9 (83.6 to 100) | 80 (62.5 to 97.5) |
| >20 | 65.7 (47.7 to 80.9) | 100 (81 to 100) | 100 (85 to 100) | 60 (42.5 to 77.5) |
| Pretreatment | ||||
| >10 | 100 (63 to 100) | 5 (0.7 to 9.3) | 7.8 (2.6 to 13) | 100 (48 to 100) |
| >15 | 100 (63 to 100) | 10 (4.1 to 15.9) | 8.3 (2.8 to 13.8) | 100 (69 to 100) |
| >20 | 87.5 (54.2 to 100) | 31 (22 to 40) | 9.2 (2.7 to 15.7) | 96.9 (88 to 100) |
| >25 | 75 (40 to 100) | 60 (50.4 to 69.6) | 14.3 (3.7 to 24.9) | 90.9 (84 to 97.6) |
| >30 | 37.5 (4 to 71) | 85 (78 to 92) | 16.7 (0 to 34.4) | 85 (78 to 92) |
Pretreatment value indicates the value of urea breath test collected before triple therapy. Posttreatment value indicates the value of urea breath test collected after the failed triple therapy.
CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.