TABLE 3.
Effect of sodium azide on the increase in ATPe level induced by the exposure of fluconazole-resistant C. albicans to hLF(1-11), fluconazole, combinations of these two compounds, or no stimulusa
| Treatment | ATPe level (M) withb:
|
|
|---|---|---|
| No azide | Azide | |
| hLF(1-11) | (2.6 ± 2) × 10−6 | (4.1 ± 2) × 10−8c |
| Fluconazole | (8.1 ± 11) × 10−7 | (1.3 ± 1) × 10−7 |
| hLF(1-11) and fluconazole | (2.1 ± 1) × 10−5 | (3.1 ± 2) × 10−6c |
| No stimulus | (3.9 ± 2) × 10−8 | (3.1 ± 1) × 10−8 |
a
Approximately 108 CFU of fluconazole-resistant C. albicans/ml were incubated with the various stimuli in the presence or absence of 5 mM sodium azide. At 2 min after stimulation, ATPe levels were measured by using an ATP determination kit.
b
Data are means ± SD from at least three independent experiments.
c
Significantly different (P < 0.05) from value obtained without azide treatment.