Table 2.
Genes Upregulated in Invasive GBM Cells.
| I/C | Accession Number | Name | Description |
| Extracellular | |||
| 7 | AA436142 | SPOCK | Sparc/osteonectin, cwcv and kasal-like domains proteglycan (testican) |
| 6 | AA425947 | DKK3/RIG | Dickkopf (Xenopus laevis) homolog 3 |
| 6 | AA115876 | PI12 | Serine (or cystein) proteinase inhibitor, clade 1 (neuroserpin) 1 |
| 4 | R76614 | NTN14 | Netrin4 |
| Transmembrane proteins | |||
| 69 | H42679 | HLA-DRA | Major histocompatibility complex, class II DM alpha |
| 8 | N62620 | KCNK1 | Potassium channel, subfamily K, member 1 (TWIK-1) |
| 7 | R38201 | OPCML | Opioid-binding protein/cell adhesion molecule-like |
| 7 | AA464590 | PTPRN2 | Protein tyrosine phosphatase receptor type, N polypeptide 2 |
| 6 | AA485795 | EFNB3 | Ephrin B3 |
| 6 | H08933 | GRIN2A | Glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| 6 | R40790 | GABRG2 | Gamma-aminobutyric acid (GABA) A receptor, gamma 2 |
| 5 | T80232 | ATX | Autotaxin (ectonucleotide pyrophosphatase/phosphodiesterase 2) |
| 5 | AA417654 | FGFR3 | Fibroblast growth factor receptor 3 |
| 5 | AA393408 | PDE1A | Phosphodiesterase 1A, calmodulin-dependent |
| 4 | W48713 | EGFR | Epidermal growth factor receptor |
| 4 | AA454743 | KLK6 | Kallikrein 6 |
| 4 | N94270 | TPARL | TPA-regulated locus |
| 3 | R17717 | CDH13 | Cadherin 13 |
| 3 | H07878 | GPRl9 | G protein-coupled receptor 19 |
| 3 | R14663 | DTR | Diphtheria toxin receptor (heparin-binding EGF-like growth factor) |
| 3 | AA479243 | AMFR | Autocrine motility factor receptor |
| Intracellular signaling | |||
| 23 | H23046 | RGS7 | Regulator of G-protein signaling 7 |
| 15 | R22326 | EHD3 | EH domain containing 3 |
| 11 | R15791 | RYR2 | Ryanodine receptor 2 (cardiac) |
| 10 | AA064973 | CS-1 | Calcineurin-binding protein calsarcin-1 |
| 6 | R69354 | SAC2 | Sac domain containing inositol phosphatase 2 |
| 4 | AA464067 | ITPK1 | Inositol 1,3,4-triphosphate 5/6 kinase |
| 3 | AA449831 | GRB2 | Growth factor receptor-bound protein 2 |
| 3 | AA454947 | AKAP1 | A kinase (PRKA) anchor protein 1 |
| 3 | AA496013 | STK2 | Serine/threonine kinase 2 |
| Cytoskeleton rearrangement | |||
| 59 | AA448015 | INA | Internexin, neuronal intermediate filament |
| 4 | R27680 | EMAP2 | Microtubule-associated protein like echinoderm EMAP |
| 4 | AA598668 | CHN1 | Chimerin (chimaerin) 1 |
| 3 | H24688 | SMARCC2 | SWI/SNF-related, matrix-associated, actin dep reg of chromatin, C2 |
| 2 | R85257 | PYK2 | Protein tyrosine kinase 2 beta |
| 2 | AA457036 | P85SPR | PAK-interacting exchange factor beta (beta-pix) |
| Apoptosis | |||
| 5 | BCL2L2 | Bcl2-like 2 (Bcl-w) | |
| 5 | T50828 | CASP7 | Caspase 7, apoptosis-related cysteine protease |
| 3 | R43325 | DAP3 | Death-associated protein 3 |
| Transcription factors | |||
| 9 | AA459941 | PEG3 | Paternally expressed 3 |
| 5 | H60572 | TRABID | TRAF-binding protein domain |
| 4 | N99243 | TBX2 | T-box 2 |
| 4 | AA234897 | MEF2C | MADS box transcription enhancer factor 2C |
| 4 | W00959 | HLF | Hepatic leukemia factor |
| 3 | R42479 | ETS2 | V-ets E26 oncogene |
| Unknown function | |||
| 77 | R67147 | CRYM | Crystallin mu |
| 16 | H54364 | MAST3 | Microtubule associated serine/threonine kinase 3 |
| 11 | H24428 | KIAA0513 | KIAA0513 gene product |
| 8 | AA452725 | NUCB1 | Nucleobindin 1 |
| 7 | AA456008 | AF1Q | ALL1-fused gene from chromosome 1q |
| 7 | W48780 | NP25 | Neuronal protein |
| 6 | W60581 | BEX1 | Brain expressed, X-linked 1 |
| 5 | AA227594 | MAL | Mal, T-cell differentiation protein |
| 4 | H19439 | DSCR1L1 | Down syndrome critical region gene 1-like 1 |
| 4 | R59579 | PGDS2 | Prostaglandin D2 synthase (21 kDa, brain) |
| 4 | H66616 | GLG1 | Golgi apparatus protein 1 |
| 3 | H22481 | NPTX1 | Neuronal pentraxin I |
| 3 | H45376 | NELL2 | Nel (chicken)-like 2 |
| 3 | T84156 | LNX | Multi-PDZ-domain-containing protein |
I/C = average cDNA microarray ratios of invasive cells over tumor core cells.