Table 2.
Time (min) | Brain | Lung | Liver | Kidney | ||||
PTER | QUER | PTER | QUER | PTER | QUER | PTER | QUER | |
5 | 5 ± 1 | 4 ± 1 | 36 ± 6 | 15 ± 3 | 14 ± 4 | 9 ± 3 | 3 ± 1 | 1 ± 0.2 |
10 | 2 ± 0.5* | 2 ± 0.4* | 15 ± 3* | 8 ± 2* | 7 ± 1* | 3 ± 1* | 3 ± 0.3 | 1 ± 0.5 |
30 | n.d. | n.d. | 6 ± 1* | 2 ± 0.6* | 3 ± 0.5* | 1 ± 0.2* | 2 ± 0.4 | n.d. |
60 | n.d. | n.d. | 2 ± 1* | n.d. | n.d. | n.d. | 1 ± 0.3* | n.d. |
Animals were treated with 20 mg of t-PTER or QUER (containing 5 µCi of 3H-t-PTER or 2 µCi of 14C-QUER) per kilogram body weight. A group of four to five mice was sacrificed for each time point.
Nondetectable = n.d.
P < .01 comparing data obtained at 10 to 60 minutes versus those found 5 minutes after polyphenol administration.