Figure 1.

Alignment of MSH6-like Protein Sequences.

Black boxes highlight identical amino acids and gray boxes highlight similar amino acids in at least three of the sequences, based on Dayhoff's PAM250 matrix. Dashes denote gaps. The sequence prefixes At-, Hs-, Sc-, and Zm- denote Arabidopsis thaliana, Homo sapiens, Saccharomyces cerevisiae, and Zea mays, respectively. Amino acid positions are shown at right. The lines above the alignment denote conserved regions found in MSH proteins: line 1, the putative N-terminal PCNA/RPA interaction domain; line 2, the N-terminal mismatch recognition domain; line 3, the middle-conserved domain; and line 4, the highly conserved C-terminal domain.