Fig. 10. Schematic representation of the possible conformations and interactions of BICD2. The BICD2 homodimer is represented by three boxes, corresponding to the three coiled-coil segments (cc1,cc2 and cc3), which are connected by lines (corresponding to putative flexible linker regions). Vesicular surface (with its coat proteins) is shown in black, and dynein and dynactin complexes as grey spheres (microtubule-BDs and microtubules are omitted for simplicity). Notice that the interaction of BICD2 with dynactin is direct, while that with dynein could be indirect. Stippled arrows indicate putative interactions of dynein and dynactin with each other and with the membrane coat; these interactions are not directly dependent on BICD2, but can be influenced by its presence in the complex.