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. 2001 Aug 1;20(15):3928–3937. doi: 10.1093/emboj/20.15.3928

graphic file with name cde408f1.jpg

Fig. 1. Schematic presentation of ATP- and PEP-dependent HPr phosphorylation. The ATP-dependent phosphorylation of HPr by HprK/P at Ser46 is stimulated by FBP, whereas dephosphorylation of P-Ser-HPr is activated by Pi. Within the PTS phosphorylation cascade, HPr is phosphorylated intermediately by EI at His15 and transfers its phosphoryl group to various EIIAs.