Table I. Specific interference with apoptosis-inducing agents by various human p53 mutations.

Mutation	Cisplatin	α-amanitin	Actinomycin D	Doxorubicin	Etoposide	DRB
143Val → Ala	+	+	–	–	+	–
248Arg → Trp	+	+	–	–	+	–
273Arg → His	+	+	–	–	+	–

–, no blocking activity; +, protective effect.