Figure 4.

Mitochondrial repair activity is inhibited by competitor heteroduplex. Repair activities of the GT5′ substrate were measured after supplementing various lysates with either a 789 bp competitor hetero- or homoduplex. Activities of both lysates are substantially inhibited by the addition of the heteroduplex (1000-fold excess), whilst the homoduplex had only a marginal effect on mitochondrial repair. Data was from three separate experiments. T-test statistical analysis: HeLa/homoduplex P = 0.060, HeLa/heteroduplex P = 0.001; Percoll/homoduplex P = 0.549, Percoll/heteroduplex P = 0.017.