Table 1. ASAT and ALAT levels in serum of NMRI nude mice treated for 14 days with LNA PO ODNS (Cur616 and Cur942) at the indicated dosages or mice treated with 0.9% saline.
| Dose (mg/kg) | Enzyme | Saline (U/l ± SEM) | Cur616 (U/l ± SEM) | Cur942 (U/l ± SEM) |
|---|---|---|---|---|
| 1 | ASAT | 150 ± 8.5 | 165 ± 32 | 139 ± 26 |
| ALAT | 49 ± 5 | 43 ± 2 | 73 ± 25 | |
| 2.5 | ASAT | 150 ± 8 | 139 ± 9 | 160 ± 19 |
| ALAT | 49 ± 5 | 38 ± 1 | 70 ± 17 | |
| 5 | ASAT | 165 ± 10 | 705 ± 204 | 348 ± 109 |
| ALAT | 45 ± 2 | 127 ± 29 | 72 ± 19 |
The enzymatic activities of ASAT and ALAT were measured in fresh mouse serum. The enzymatic activities are expressed as U/l at 37°C ± SEM.