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. 2003 Feb 1;31(3):1097–1107. doi: 10.1093/nar/gkg192

Figure 1.

Figure 1

Human ABCA2 5′-flanking DNA from –549 to +397 bp relative to ATG translation start site. The putative ABCA2 promoter region DNA sequence is shown with upper case letters comprising the 5′-flanking DNA and first exon and the lower case letters comprising the beginning of the first intron. The numbering of the DNA sequence is in base pairs relative to the ATG start site, depicted in bold. The large arrow depicts the major transcription start site and the small arrow depicts a minor transcription start site. Binding sites that match the consensus DNA sequence as listed in the TRANSFAC database are lined, including HNF-3, EGR-1, Sp1, c-myc and AP1. Of particular note are two GC-boxes at positions –195 and –108 bp that contain overlapping 13 bp recognition sites for the transcription factors EGR-1 and Sp1.