Table 4.

Adjusted Odds Ratios for Nonadherence to Statin Therapy

	Definition of Non-Adherence
	CMG <10%	CMG <20%	CMG <30%
Variable	Odds Ratio (95% Confidence Interval)
Age < 65 years	1.25 (1.08 to 1.45)	1.31 (1.13 to 1.52)	1.26 (1.07 to 1.49)
Gender, female	1.24 (1.10 to 1.40)	1.13 (1.01 to 1.29)	—
Race, African-American *	1.73 (1.35 to 2.21)	1.97 (1.57 to 2.48)	2.13 (1.69 to 2.69)
LDL tests per year †	0.96 (0.95 to 0.98)	0.97 (0.96 to 0.99)	0.97 (0.96 to 0.99)
Copay, $10 to <$20‡	1.45 (1.25 to 1.69)	1.30 (1.11 to 1.51)	1.25 (1.06 to 1.48)
Copay, ≥$20‡	3.23 (2.55 to 4.10)	3.11 (2.48 to 3.89)	2.73 (2.16 to 3.45)
Multiple brands or strengths tried	1.41 (1.24 to 1.61)	1.40 (1.22 to 1.59)	1.48 (1.28 to 1.70)
Multiple doses per day	1.88 (1.55 to 2.27)	1.71 (1.43 to 2.05)	1.61 (1.33 to 1.94)
Average days supply, 0 to <35§	2.17 (1.77 to 2.65)	2.43 (1.93 to 3.06)	3.58 (2.66 to 4.82)
Average days supply, 35 to <65§	1.74 (1.43 to 2.12)	1.91 (1.51 to 2.40)	2.59 (1.92 to 3.49)

CMG thresholds indicate the number of days without therapy over the number of days the patient was actively taking statin, expressed as a percentage. Model developed through forward stepwise selection with all predictor variables required to maintain a minimal significance of P< .05.

^* Reference group = patients who self-identified as “white.”

^† For each additional unit.

^‡ Reference group = patients whose average monthly prescription copayment was less than $10.

^§ Reference group = patients whose average days supply per prescription was 65 or greater.

CMG, cumulative multiple refill-interval gap.