Table 1.
Classification of ACE Inhibitor Therapy Dose Range (mg/day)
| ACE Inhibitor Therapy | Low | Medium | High |
|---|---|---|---|
| Benazepril HCl * | 5 | 6 to 19 | 20 |
| Captopril †‡ | 38 | 39 to 149 | 150 |
| Cilazapril * | 1.25 | 1.26 to 4 | 5 |
| Enalapril maleate †‡ | 5 | 6 to 19 | 20 |
| Fosinopril sodium * | 5 | 6 to 19 | 20 |
| Lisinopril † | 5 | 6 to 19 | 20 |
| Perindopril erbumine * | 2 | 3 to 7 | 8 |
| Quinapril HCl † | 10 | 11 to 39 | 40 |
| Ramipril * | 2.5 | 2.6 to 9 | 10 |
High doses based on the highest recommended maintenance dose in the Compendium of Pharmaceuticals and Specialties.24
Analysis repeated for lisinopril high dose of 32.5 mg or greater and low dose 5 mg of less.
High dose based on the ACE inhibitor target doses recommended by the Agency for Health Care Policy and Research for the management of heart failure.23
High dose based on randomized controlled trial (RCT) evidence.
ACE, angiotensin-converting enzyme.