Table 3.

Physical Symptom Improvement According to the Level of Depression Response

	Improvement in Pain Symptoms at 1 and 3 Months†			Improvement in Nonpain Symptoms at 1 and 3 Months†
	Mean (SD)	Change—Effect Size‡		Mean (SD)	Change—Effect Size‡
Depression Response*	Baseline	1 Month	3 Months	Baseline	1 Month	3 Months
Remitters	3.7 (1.9)	0.6	0.6	6.1 (2.8)	0.7	0.9
Partial responders	4.6 (2.1)	0.8	0.7	8.5 (2.9)	0.9	1.0
Nonresponders	5.0 (2.1)	0.5	0.3	8.2 (2.8)	0.5	0.4

^*Remitters were defined as having a Hopkins Symptom Checklist modified depression subscale (HSCL-20) score ≤0.5 after 3 months of antidepressant treatment, while partial responders had a≥50% improvement in SCL-20 score but not to a level≤0.5. Patients who did not meet either criterion were placed in the nonresponders group.

^†Patient Health Questionnaire physical symptom score for the 5-item pain score ranges from 0 (no pain) to 10 (worst pain), and for the 9-item nonpain score ranges from 0 (asymptomatic) to 18 (most symptomatic).

^‡To standardize comparisons among domains, change was measured in effect size, which is the mean change divided by the pooled standard deviation for a measure.

SD, standard deviation.