TABLE 1.

Antibacterial effect measures for each strain of S. pneumoniae with each moxifloxacin dose simulation

Strain (MIC, mg/liter)	Dose regimen			Viable counts (log CFU/ml)				AUBKC0-72 (log CFU/ml · h)	T99.9 (h)
	mg	Interval between doses (h)	n	Δ24	Δ48	Δ72	Δmax
11622 (0.25)	400	24	3	−1.7 ± 1.1	−5.4 ± 0.8	−2.9 ± 0.2	−5.7 ± 0.5	220 ± 8	30 ± 6
	400	12	3	−4.8 ± 0.5	−4.2 ± 1.0	−3.4 ± 1.2	−5.2 ± 0.5	150 ± 24	16 ± 7
	800	24	3	−4.6 ± 1.5	−4.5 ± 1.2	−5.4 ± 0.2	−5.4 ± 0.2	124 ± 22	18 ± 12
12716 (1.0)	400	12	5	−3.3 ± 1.8	−5.7 ± 0.6	−6.2 ± 0.7	−6.2 ± 0.7	159 ± 44	19 ± 8
	800	24	3	−1.9 ± 1.1	−6.3 ± 0.8	−6.0 ± 1.2	−6.7 ± 0.1	174 ± 28	29 ± 6
12648 (3.6)	400	24	3	+0.6 ± 0.6	+0.2 ± 0.4	+0.6 ± 0.6	−0.1 ± 0.1	456 ± 35	>72
	400	12	3	+0.2 ± 0.7	+0.3 ± 0.2	+0.5 ± 0.4	−0.6 ± 0.4	440 ± 24	>72
	800	24	3	−0.5 ± 0.5	+0.2 ± 0.2	−0.1 ± 0.3	−0.9 ± 0.1	425 ± 22	>72