TABLE 3.

Emergence of resistance to moxifloxacin in three strains of S. pneumoniae^a

Strain (MIC, mg/liter)	Moxifloxacin concn in recovery medium (×)	Log CFU/liter at the following time (h) with the indicated dose regimen:
		0	24			48			72
			400 every 24 h	400 every 12 h	800 every 24 h	400 every 24 h	400 every 12 h	800 every 24 h	400 every 24 h	400 every 12 h	800 every 24 h
11622 (0.25)	0	7.8 ± 0.6	6.6 ± 0.9	<2	2.9 ± 1.4	5.8	3.0 ± 1.1	2.8 ± 1.1	5.2 ± 0.2	<2	<2
	1	4.6 ± 2.1	<2	<2	<2	3.5 ± 1.4	<2	2.7 ± 0.9	5.2 ± 0.1	<2	<2
	2	<2	<2	<2	<2	2.8 ± 0.9	<2	<2	<2	<2	<2
	4	<2	<2	<2	<2	2.6 ± 0.6	<2	<2	<2	<2	<2
12716 (1.0)	0	8.6 ± 0.2	ND	5.1 ± 2.0	6.9 ± 1.1	ND	2.5 ± 0.4	<2	ND	<2	<2
	1	<2	ND	<2	<2	ND	<2	<2	ND	<2	<2
	2	<2	ND	<2	<2	ND	<2	<2	ND	<2	<2
	4	<2	ND	<2	<2	ND	<2	<2	ND	<2	<2
12648 (3.6)	0	7.9 ± 0.4	8.1 ± 0.1	8.2 ± 0.1	7.6 ± 0.7	8.2 ± 0.6	8.3 ± 0.1	8.2 ± 0.1	5.2	2.5	3.2 ± 1.7
	1	<2	5.1 ± 0.3	4.9 ± 0.3	<2	4.9 ± 0.4	3.0 ± 0.9	5.1 ± 0.1	<2	<2	<2
	2	<2	<2	<2	<2	<2	<2	<2	<2	<2	<2
	4	<2	<2	<2	<2	<2	<2	<2	<2	<2	<2

^aSee Table 2, footnote a. Doses are given in milligrams.