TABLE 4.
Emergence of resistance to moxifloxacin in two strains of P. aeruginosaa
| Strain (MIC, mg/liter) | Moxifloxacin concn in recovery medium (×) | Log CFU/liter at the following time (h) with the indicated dose regimen:
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 24
|
48
|
72
|
|||||||||||
| 200 every 24 h | 400 every 24 h | 400 every 12 h | 800 every 24 h | 200 every 24 h | 400 every 24 h | 400 every 12 h | 800 every 24 h | 200 every 24 h | 400 every 24 h | 400 every 12 h | 800 every 24 h | |||
| 21356 (0.25) | 0 | 8.5 ± 0.2 | 8.3 ± 0.1 | 7.6 ± 0.6 | 7.5 ± 0.6 | 7.5 ± 0.5 | 8.2 ± 0.1 | 7.5 ± 0.5 | 5.3 ± 1.7 | 7.3 ± 0.8 | 8.3 ± 0.1 | 8.2 ± 0.1 | 7.6 ± 0.9 | 7.5 ± 0.9 |
| 1 | 8.1 ± 0.2 | 8.2 ± 0.1 | 7.4 ± 0.8 | 7.5 ± 0.8 | 7.4 ± 0.5 | 8.2 ± 0.1 | 7.4 ± 0.5 | 5.2 ± 1.9 | 7.0 ± 1.0 | 8.2 ± 0.1 | 8.2 ± 0.1 | 6.9 ± 1.1 | ND | |
| 2 | 6.5 ± 1.7 | 8.1 ± 0.1 | 7.5 ± 0.7 | 3.8 ± 0.2 | 5.8 ± 0.9 | 8.2 ± 0.1 | 7.4 ± 0.5 | 4.9 ± 2.1 | 4.6 ± 1.1 | 8.2 ± 0.1 | 8.2 ± 0.1 | 6.4 ± 1.6 | ND | |
| 4 | 4.7 ± 1.5 | 8.0 ± 0.1 | 7.3 ± 0.8 | 2.6 ± 0.5 | 3.5 ± 1.0 | 8.1 ± 0.1 | 7.3 ± 0.6 | 2.9 ± 1.1 | 2.8 ± 1.1 | 8.0 ± 0.1 | 8.2 ± 0.1 | 4.0 ± 2.4 | 4.0 ± 0.4 | |
| 8 | 4.0 ± 1.5 | 7.7 ± 0.2 | 5.9 ± 1.6 | <2 | 2.9 ± 1.0 | 7.8 ± 0.1 | 7.2 ± 0.6 | <2 | <2 | 8.0 ± 0.1 | 8.2 ± 0.1 | 3.8 ± 3.1 | 3.6 ± 1.4 | |
| 16 | <2 | ND | 3.4 ± 1.6 | <2 | <2 | ND | 5.0 ± 0.6 | 3.8 ± 3.1 | <2 | ND | 8.3 ± 0.2 | 3.2 ± 1.8 | 3.5 ± 1.4 | |
| 20574 (1.0) | 0 | 8.6 ± 0.2 | ND | ND | 6.8 ± 0.8 | 8.2 | ND | ND | 7.3 ± 0.5 | 8.3 ± 0.3 | ND | ND | 8.3 | 8.0 ± 0.5 |
| 1 | 5.3 ± 0.3 | ND | ND | 6.0 ± 0.8 | 5.8 ± 1.0 | ND | ND | 7.2 ± 0.6 | 8.4 ± 0.4 | ND | ND | 8.1 | 8.3 ± 0.1 | |
| 2 | 4.4 ± 1.2 | ND | ND | 4.8 ± 0.2 | 4.7 ± 1.3 | ND | ND | 6.8 ± 0.2 | 8.2 ± 0.2 | ND | ND | 7.7 ± 0.9 | 8.2 ± 0.1 | |
| 4 | 3.8 ± 1.0 | ND | ND | 4.5 ± 0.1 | 4.7 ± 1.3 | ND | ND | 7.3 ± 0.7 | 8.2 | ND | ND | 8.2 ± 0.2 | 8.2 ± 0.2 | |
| 8 | 2.6 ± 0.6 | ND | ND | 4.1 ± 0.6 | 4.6 ± 1.1 | ND | ND | 6.3 ± 0.9 | 8.0 | ND | ND | 8.0 ± 0.4 | 7.4 ± 1.2 | |
| 16 | <2 | ND | ND | 3.5 ± 1.0 | 3.1 ± 0.1 | ND | ND | 6.6 ± 0.9 | 3.9 ± 2.0 | ND | ND | 7.7 ± 0.6 | 6.5 ± 1.3 | |
a
See Table 2, footnote a. Doses are given in milligrams.