TABLE 5.
Emergence of resistance to moxifloxacin in S. pneumoniae and P. aeruginosa strains, as measured by changes in AUC for PAPa
| Strain (MIC, mg/liter) | Species | Dose simulation
|
AUC for PAP at the following times (h) postexposure:
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| mg | Interval between doses (h) | 12 | 24 | 36 | 48 | 60 | 72 | ||
| 11622 (0.25) | S. pneumoniae | 400 | 24 | 3.1 ± 0.2 | 2.4 ± 0.5 | <1 | 4.7 ± 4.2 | ND | 9.7 ± 4.8 |
| 400 | 12 | 2.1 ± 1.4 | <1 | 2.9 ± 5.1 | <1 | <1 | <1 | ||
| 800 | 24 | 3.0 ± 2.2 | 1.2 ± 2.1 | <1 | 1.1 ± 1.4 | 1.5 ± 1.3 | 4.4 ± 8.8 | ||
| 12716 (1.0) | S. pneumoniae | 400 | 12 | 3.0 ± 0.1 | 1.1 ± 1.1 | <1 | <1 | <1 | <1 |
| 800 | 24 | 3.1 ± 0.3 | 2.4 ± 0.6 | <1 | <1 | <1 | <1 | ||
| 12648 (3.6) | S. pneumoniae | 400 | 24 | 5.8 ± 0.5 | 6.4 ± 0.5 | 6.2 ± 0.8 | 6.0 ± 0.6 | 6.4 ± 1.2 | 7.9 ± 2.7 |
| 400 | 12 | 3.8 ± 1.6 | 6.0 ± 0.3 | 4.1 ± 1.1 | 4.0 ± 0.8 | 5.3 | 3.6 | ||
| 800 | 24 | 3.3 ± 0.8 | 3.8 ± 1.7 | 6.2 ± 6.1 | 6.3 ± 0.1 | 5.7 ± 0.9 | 4.2 | ||
| 21356 (0.25) | P. aeruginosa | 200 | 24 | 62.7 ± 1.9 | 75.9 ± 3.0 | 79 ± 3.6 | 79.8 ± 3.5 | 81.3 ± 2.4 | 83.7 ± 0.6 |
| 400 | 24 | 59.1 ± 15.7 | 61.0 ± 18.5 | 75.7 ± 6.1 | 75.7 | ND | 99.6 ± 1.2 | ||
| 400 | 12 | 15.4 ± 2.5 | 13.8 ± 3.5 | 9.7 ± 1.9 | 13.8 ± 7.0 | 41 ± 32.5 | 34.1 ± 29 | ||
| 800 | 24 | 30.7 ± 8.3 | 23.1 ± 7.8 | 19.4 ± 8.9 | 15.9 ± 6.7 | 27 ± 11.5 | 28 ± 14.2 | ||
| 20574 (1.0) | P. aeruginosa | 400 | 12 | 24.7 ± 6.1 | 36.5 ± 6.7 | 59 ± 24.3 | 72.9 ± 9.3 | 93.7 ± 5.2 | 95.2 |
| 800 | 24 | 13.7 ± 7.1 | 32.2 ± 15.4 | 58.8 ± 19.6 | 74.7 ± 18.3 | 80.8 ± 15.7 | 87.7 ± 12.9 | ||
a
ND, not determined.