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Toxicities of FLP-102 and FLP-105 for mice. BALB/c mice were treated with single intraperitoneal bolus injections of mutant recombinant PAP FLP-102 or FLP-105 or native PAP at the indicated dose levels. Survival curves for mice treated with the specified PAPs at specific dose levels are depicted. None of the 99 mice treated with FLP-102 or FLP-105 at dose levels ranging from 50 to 150 μg/mouse became sick or died within the 30-day observation period.
