TABLE 1.
Interindividual variability of RTV and PI Cmins
| Treatmenta | n | PI
|
RTV
|
||||
|---|---|---|---|---|---|---|---|
| Mean Cmin (ng/ml) | SD (ng/ml) | CVb (%) | Mean Cmin (ng/ml) | SD (ng/ml) | CV (%) | ||
| APV | |||||||
| 1,200/0 | 10 | 300 | 185 | 61.6 | |||
| 600/100 | 58 | 1,756 | 791 | 45.0 | 142 | 85 | 59.9 |
| IDV | |||||||
| 800/0 TID | 29 | 361 | 659 | 182.6 | |||
| 800/100 | 104 | 1,267 | 999 | 78.8 | 551 | 526 | 95.3 |
| 600/100 | 97 | 855 | 787 | 92.0 | 562 | 428 | 76.1 |
| 400/100 | 40 | 571 | 437 | 76.5 | 568 | 407 | 71.7 |
| NFV | |||||||
| 1,250/0 | 90 | 1,841 | 1,275 | 69.3 | |||
| 1,250/100 | 11 | 3,385 | 2,525 | 74.6 | 308 | 307 | 99.9 |
| SQV | |||||||
| 800/100 | 40 | 792 | 842 | 106.4 | 599 | 467 | 77.9 |
| 600/100 | 18 | 620 | 519 | 83.7 | 500 | 354 | 70.8 |
| LPV, 400/100 | 45 | 4,650 | 2,398 | 51.6 | 200 | 115 | 57.4 |
a
The PI/RTV treatment is shown with the PI dose (APV, IDV, NFV, SQV, or LPV) before the slash and the RTV dose after the slash. Both doses are given in milligrams, and the drugs were administered BID unless stated otherwise.
b
CV, coefficient of variation.