TABLE 2.
In vitro activities of cefotaxime and erythromycin individually and in combination against S. pneumoniae
| Serotype (isolate no.) | MIC (μg/ml)
|
FICI | Interactive category | ||
|---|---|---|---|---|---|
| Cefotaxime | Erythromycin | Cefotaxime-erythromycin combination | |||
| Cefotaxime susceptible, erythromycin susceptible | |||||
| 1 (364.0344) | 0.016 | 0.0625 | 0.016/0.0625 | 3 | Indifference |
| 12 (005.0358) | 0.016 | 0.1250 | 0.016/0.250 | 4 | Antagonism |
| 12 (1014) | 0.016 | 0.0625 | 0.016/0.125 | 3 | Indifference |
| Cefotaxime susceptible, erythromycin resistant | |||||
| 7 (315.0353) | 0.016 | 8.000 | 0.016/8.000 | 2.0 | Indifference |
| 38 (0865) | 0.062 | 2.000 | 0.016/2.000 | 1.25 | Indifference |
| 6 (4828) | 0.125 | 4.000 | 0.125/8.000 | 3 | Indifference |
| Cefotaxime resistant, erythromycin sensitive | |||||
| 19 (2660) | 8.000 | 0.250 | 4.00/0.250 | 1.5 | Indifference |