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Binding affinity for PBPs of E. coli
| Compound | IC50 (μg/ml)
|
MIC (μg/ml)a | ||||||
|---|---|---|---|---|---|---|---|---|
| PBP1A | PBP1B | PBP2 | PBP3 | PBP4 | PBP5 | PBP6 | ||
| S-3578 | 5.8 | 4.3 | >16 | 0.18 | >16 | >16 | >16 | 0.25 |
| Cefepime | >4 | 3.4 | 0.29 | 0.021 | >4 | >4 | >4 | 0.03 |
| Ceftriaxone | 0.092 | 0.24 | 0.30 | 0.013 | >4 | >4 | >4 | 0.06 |
MIC for E. coli NIHJ JC-2, the membrane fraction of which was employed for determination of IC50s.
