TABLE 1.
PAEs, SMEs, and PA-SMEs of garenoxacin against 12 strains
| Straina | Mean effect (h)b
|
||||||
|---|---|---|---|---|---|---|---|
| PAE | 0.2× MIC
|
0.3× MIC
|
0.4× MIC
|
||||
| SMEc | PA-SMEd | SME | PA-SME | SME | PA-SME | ||
| Pen-S S. pneumoniae | 1.2 (0.8-1.6) | 1.0 (0-2.0) | 3.4 (2.2-4.5) | 1.2 (0.5-2.0) | 4.7 (4.3-5.1) | 1.8 (1.1-2.4) | 5.0 (4.3-5.6) |
| Pen-S S. pneumoniae | 2.2 (2.0-2.5) | 2.6 (2.4-2.9) | 3.2 (2.5-3.9) | 3.3 (3.3-3.3) | ≥8.4 (6.9->9.8) | 4.2 (3.5-4.8) | >9.4 (>9.4->9.4) |
| Pen-I S. pneumoniae | 1.6 (1.5-1.8) | 1.8 (1.5-2.1) | 2.2 (1.9-2.6) | 1.6 (1.3-1.8) | 2.4 (1.9-2.8) | 2.0 (1.6-2.3) | 3.0 (2.9-3.1) |
| Pen-I S. pneumoniae | 1.2 (0.8-1.6) | 0.8 (0.4-1.1) | 1.1 (0.8-1.4) | 1.3 (1.3-1.3) | 2.2 (2.2-2.3) | 2.4 (2.4-2.5) | 3.1 (3.0-3.1) |
| Pen-R S. pneumoniae | 0.8 (0.5-1.0) | 1.7 (1.5-1.9) | 2.2 (1.8-2.6) | 3.7 (3.5-3.9) | 6.2 (5.8-6.6) | ≥10 (10-≥10.2) | >10 (>10->10.2) |
| Pen-R S. pneumoniae | 0.3 (0-0.6) | 0.4 (0.3-0.5) | 0.7 (0.3-1.1) | 1.2 (1.1-1.3) | 1.4 (1.1-1.6) | 1.2 (1.1-1.3) | 5.2 (5.1-5.3) |
| E. faecalis | 1.0 (0.3-1.6) | 0.7 (0.6-0.8) | 2.4 (1.3-3.4) | 2.0 (1.9-2.0) | 3.4 (2.7-4.0) | 3.8 (3.8-3.8) | 5.8 (4.8-6.9) |
| Meth-S S. aureus | 0.8 (0.7-0.8) | 1.3 (1.0-1.6) | 2.2 (1.9-2.6) | 2.9 (2.1-3.7) | 7.7 (6.7-8.7) | >10.7 (>10.7->10.7) | >10.7 (>10.7->10.7) |
| Meth-R, cipro-S S. aureus | 0.6 (0.6-0.7) | 0.3 (0.3-0.3) | 1.3 (1.2-1.4) | 0.6 (0.5-0.8) | 2.2 (1.5-2.8) | 0.9 (0.5-1.3) | 4.3 (4.0-4.6) |
| Meth-R, cipro-R S. aureus | 0.6 (0.1-1.2) | 0.3 (0.2-0.4) | 1.0 (0.9-1.2) | 0.3 (0.2-0.4) | 1.2 (1.1-1.2) | 1.1 (0.4-1.8) | 1.8 (1.3-2.2) |
| E. coli | 0.9 (0.8-1.0) | 1.1 (0.7-1.5) | 2.8 (2.4-3.3) | 2.2 (2.0-2.5) | 4.6 (4.2-5.1) | 4.5 (4.0-5.0) | 7.6 (7.5-7.8) |
| P. aeruginosa | 1.6 (1.2-2.1) | 1.6 (1.2-1.9) | 2.7 (2.5-2.9) | 2.2 (2.0-2.3) | 4.0 (4.0-4.0) | 3.8 (3.2-4.4) | 4.4 (4.0-4.9) |
a
Pen-S, Pen-I, and Pen-R, penicillin-susceptible, -intermediate, and -resistant, respectively; Meth-S and Meth-R, methicillin-susceptible and -resistant, respectively; cipro-S and cipro-R, ciprofloxacin-susceptible and -resistant, respectively.
b
Values are means of two separate experiments. Values in parentheses are ranges. Strains were exposed to 6 to 10 times the MIC of garenoxacin (see text) for 1 h at 35°C. The drug was removed by 1:1,000 dilution.
c
Strains were not previously exposed to garenoxacin.
d
Strains were previously exposed to garenoxacin.