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Anti-HIV-1 activity of WM5 on virus-encoded enzymes
| Compound | IC50 (μM)a
|
|||
|---|---|---|---|---|
| RT | IN
|
PR | ||
| 3′ processing | Strand transfer | |||
| WM5 | 800 ± 150 | 60 ± 20 | 75 ± 15 | 71 ± 21 |
| WM5E | >100 | >100 | ||
| RDS 1028 | 0.4 ± 0.2 | 0.3 ± 0.2 | ||
| Saquinavir | 0.002 ± 0.00035 | |||
IC50, concentration of compound required to reduce the HIV-1 enzyme-catalyzed reactions by 50%. PR, protease. All data represent means ± standard deviations obtained in three separate experiments.
