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. 2003 Mar;47(3):956–964. doi: 10.1128/AAC.47.3.956-964.2003

FIG. 5.

FIG. 5.

L-685,818 demonstrates synergy with fenpropimorph (Fenp) and terbinafine (Terb) against wild-type C. albicans. Although less potent than FK506, the nonimmunosuppressive FK506 analog L-685,818 demonstrates drug synergy with fenpropimorph and terbinafine against wild-type C. albicans in halo assays. Wild-type C. albicans (SC5314) cells were grown overnight in YPD medium and treated the same as in the experiment described in Fig. 2. As indicated, disks containing 2 μg of FK506, 4 μg of L-685,818, 2 μg of fenpropimorph, and 10 μg of terbinafine were placed over the solidified top agar. Cells were incubated for 24 to 48 h at 37°C.

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