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. 2003 Mar;47(3):956–964. doi: 10.1128/AAC.47.3.956-964.2003

TABLE 2.

Synergism between ergosterol biosynthesis inhibitors and calcineurin inhibitors is FKBP12 and calcineurin dependent

Genotype (C. albicans strain) MIC100 alone (μg/ml)a
MIC100 combineda,b
FIC indexa
CsA FK506 F T CsA/F CsA/T FK506/F FK506/T CsA/F CsA/T FK506/F FK506/T
Wild type (SC5314) >3.12 >3.12 3.12 >10.5 1.56/0.04 0.78/3.12 ≤0.04/≤0.01 0.09/0.39 0.26 0.24 0.004 0.03
cnb1/cnb1 (DAY364) >3.12 >3.12 ≤0.01 0.39 ≤0.04/≤0.01 ≤0.04/0.39 ≤0.04/≤0.01 ≤0.04/0.39 1.003 1.003 1.003 1.003
cnb1/cnb1 CNB1 (MCC85) >3.12 >3.12 0.78 >12.5 0.78/0.04 0.19/3.12 ≤0.04/≤0.01 ≤0.04/0.78 0.17 0.15 0.009 0.03
CNB1-1/CNB1 (YAG237) >3.12 >3.12 3.12 >12.5 1.56/0.19 0.78/3.12 >3.12/3.12 >3.12/>12.5 0.31 0.25 2.0 2.0
rbp1/rbp1 (YAG171) >3.12 >3.12 3.12 >12.5 0.19/0.78 0.39/1.56 >3.12/3.12 >3.12/>12.5 0.28 0.12 2.0 2.0
a

F, fenpropimorph; T, terbinafine.

b

Combined MICs, expressed as [drug 1]/[drug 2] are the minimum concentrations of drugs 1 and 2 required to inhibit cell growth when the two drugs were used in combination.

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