TABLE 4.
MICs for and detected mutations in 31 high-level macrolide-resistant H. influenzae isolates
| Strain | MIC (μg/ml) of:
|
Mutation(s)a
|
|||
|---|---|---|---|---|---|
| Azithromycin | Clarithromycin | L4 | L22 | 23S rRNA | |
| S30 | >64 | >64 | A2058G | ||
| S43 | >64 | >64 | A2058G, G2160U | ||
| S4 | 8 | 64 | INS 63GT | ||
| S27 | 16 | >64 | G65D | ||
| S37 | 16 | 64 | K61Q | ||
| S39 | 16 | 64 | T64K | ||
| S47 | 8 | 64 | G65D | ||
| S50 | 32 | 32 | A69S | ||
| S54 | 64 | 64 | T82I | ||
| S1 | 32 | >64 | INS 77DEGPSM | ||
| S2 | 8 | 16 | G91D | ||
| S3 | 8 | 16 | G91D | ||
| S23 | 8 | 32 | DEL 96ILK | ||
| S26 | 32 | >64 | INS 88RAKG | ||
| S40 | 64 | >64 | DEL 95RI | ||
| S42 | 8 | 32 | DEL 81S | ||
| S49 | 64 | 32 | INS 91KG | ||
| S53 | >64 | 64 | DEL 82M | ||
| S58 | >64 | >64 | INS 91RAG | ||
| S60 | 16 | 16 | INS 91RADR | ||
| S34 | >64 | >64 | DEL 95RI | GGA2160-2162UAU | |
| S36 | 16 | >64 | D139G | G2160U | |
| S44 | >64 | >64 | T64K | G91D | |
| S57 | >64 | >64 | T64K | G91D | |
| S61 | >64 | >64 | D94E | DEL 96ILKR | |
| S35 | 32 | >64 | T64K | G91D | C2164G |
| S38 | 16 | 64 | T64K | G91D | C2164G |
| S41 | 8 | 32 | T64K | G91D | C2164G |
| S51 | 32 | >64 | |||
| S52 | >64 | >64 | |||
| S59 | 32 | >64 | |||
a
INS, insertion; DEL, deletion. Position numbers for L4 and L22 are based on the H. influenzae numbering system, and those for 23S rRNA are based on the E. coli numbering system.