Table 8.
The effect on IMV entry of staurosporin, calphostin C and tryphostin 23 on HeLa cells overexpressing L61rac1
Drug concentration | Nontransfected cells (%) | L61rac1 transfected cells (%) |
---|---|---|
Control | 100a | 100b |
Staurosporin (100 nM) | 55 | 88 |
Staurosporin (200 nM) | 27.5 | 73 |
Calphostin C (200 nM) | 34 | 89 |
Calphostin C (400 nM) | 10 | 79 |
Tyrphostin 23 (50 μM) | 31 | 39 |
Tyrphostin 23 (100 μM) | 17 | 16 |
The average number of cores in untreated and nontransfected cells was taken as 100%.
The average number of cores in untreated and transfected cells was taken as 100%. In each case the cores in 25 cells were counted and the values are the average of two independent experiments.