Figure 3.

Inheritance of the 1B4 provirus. Mice heterozygous for the 1B4 provirus were crossed and their progeny were analyzed by Southern blot analysis following EcoR1 digestion and hybridization to the 1B4 flanking sequence. (A) Representative Southern blot hybridization patterns for wild-type (+/+), heterozygous (+/-), and homozygous mutant (-/-) mice. (B) Inheritance of the 1B4 provirus follows a Mendelian distribution as assessed by the distribution of genotypes of progeny from intercrossing 1B4 heterozygotes.