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. 1989 Mar;209(3):307–311. doi: 10.1097/00000658-198903000-00010

Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III.

T Bauer 1, B Vennits 1, B Holm 1, J Hahn-Pedersen 1, D Lysen 1, H Galatius 1, E S Kristensen 1, P Graversen 1, F Wilhelmsen 1, H Skjoldborg 1, et al.
PMCID: PMC1493927  PMID: 2647050

Abstract

In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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