Figure 7.

Model for the regulation of TRX2 expression by Tsa1p. The data suggest that thioredoxin peroxidase may regulate the expression of thioredoxin through the activity of the Skn7p and Yap1p transcription factors. This regulation by Tsa1p could involve the direct regulation of the redox status of Skn7p and/or Yap1p. Alternatively, the redox status of an interacting regulatory protein or the phosphorylation state of Skn7p and/or Yap1p could be regulated. It is possible that the affect of Tsa1p is indirect, i.e., that it alters the redox status of one or more members of the thioredoxin pathway and that this protein is the regulatory element for OS–induced expression of TRX2. The arrows between the proteins of the thioredoxin system represent changes in the redox status of the proteins, and YRE represents the Yap1p-binding sites.