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Dose-dependent inhibition of NF-κB activation by the MOD. 293 cells were cotransfected with the indicated amounts of expression vectors for wild-type IKKγ, IKKγ1-196, or IKKγ246-365, NF-κB reporter plasmid 6xNF-κBluc, and an internal control plasmid. After stimulation of the cells with TNF-α for 6 h, luciferase activity was measured.
