Characteristics of Guidelines

Guideline	Framingham	U.S. NCEP ATP III	Joint European	Joint British	Revised Sheffield	PROCAM
Database	Framingham Heart Study	Framingham Heart Study	Framingham Heart Study	Framingham Heart Study	Framingham Heart Study	Munster Heart Study
Parameters considered for risk estimation	Sex	Sex	Sex	Sex	Sex	Age
	Age	Age	Age	Age	Age	SBP
	SBP	SBP	SBP	SBP	Hypertension	Smoking
	Smoking	Smoking	Smoking	Smoking	Smoking	Diabetes mellitus
	Diabetes mellitus	Diabetes mellitus	Diabetes mellitus	Diabetes mellitus	Diabetes mellitus	LDL cholesterol
	Total cholesterol	Total cholesterol	Total cholesterol	Ratio of total to HDL cholesterol	Total cholesterol	HDL cholesterol
	HDL cholesterol	HDL cholesterol		HDL cholesterol	ECG-LVH	Trigycerides
	ECG-LVH					Family history of heart attack
Applicability of guidelines	Age: 30–74 y	Age: 20–79 y	Age: 30–70 y	Age: 35–74 y	Age: ≤70 y	Sex: men
			SBP: 110–190 mg/dL	SBP: 110–190 mmHg		Age: 40–65 y
			TC: 125–325 mg/dL	TC:HDL ratio: 3:11		SBP: 100–225 mmHG
						LDL-C: 75–250 mg/dL
						HDL-C: 25–75 mg/dL
						TG: 50–400 mg/dL
Handling of diabetic patients	No separate chart for CHD risk estimation	Considered as high-risk patients (CHD risk >20%/10 y)	Separate chart for CHD risk estimation	Separate chart for CHD risk estimation	No separate chart for CHD risk estimation	No separate chart for CHD risk estimation
Recommendations concerning lipid-lowering therapy	No	Yes (depending on LDL-C, CHD risk and number of risk factors)	Yes (CHD risk ≥20% over 10 y and TC ≥190 mg/dL and/or LDL-C ≥115 mg/dL)	Yes (CHD risk ≥15% over 10 y and TC ≥5 mmol/L)	Yes (CHD risk ≥3%/y)	No

SBP, systolic blood pressure; ECG-LVH, electrocardiogram-center ventricular hypertrophy; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides.