FIG. 1.

Schematic of LMP-1 and LMP-1 variants used in this study: comparison of full-length LMP-1, TMD1,2, TMD1,2Δ55/mycHis, lyLMP-1, Δ25-132, and mycASGPR/LMP-1. TMD1,2 lacks TMDs 3 to 6; TMD1,2Δ55/mycHis is a Myc- and His-tagged deletion of TMD1,2 lacking residues 331 to 386 of LMP-1; lyLMP-1 lacks the cytoplasmic N terminus and first four TMDs (residues 1 to 128); Δ25-132 is essentially lyLMP-1 with the wild-type LMP-1 cytoplasmic N terminus fused to TMD 5 (15); mycASGPR/LMP-1 is a chimera in which LMP-1's cytoplasmic N terminus was replaced with a Myc-tagged heterologous N terminus from the H1 asialoglycoprotein receptor (ASGPR) (4).