TABLE 2.
Zanamivir IC50 values for each clinical isolate in three NI assays
| Influenza virus type | Isolate | IC50 (nM) in the following assay:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CL assay (n = 12)
|
FA-1 (n = 12)
|
FA-2 (n = 6)
|
||||||||
| Mean (SD) | CV | Rangea (fold change) | Mean (SD) | CV | Rangea (fold change) | Mean (SD) | CV | Rangea (fold change) | ||
| B | 97012351 | 1.00 (0.14) | 13.90 | 0.76-1.26 (0.7) | 6.77 (10.14) | 149.89 | 0.51-26.40 (50.8) | 4.66 (3.14) | 67.37 | 0.69-7.67 (10.1) |
| 97012942 | 1.07 (0.17) | 15.88 | 0.81-1.35 (0.7) | 5.28 (8.84) | 167.42 | 0.65-27.70 (41.6) | 5.19 (3.65) | 70.26 | 0.53-8.22 (14.5) | |
| 97013118 | 1.40 (0.37) | 26.58 | 1.04-2.51 (1.4) | 4.49 (8.34) | 185.89 | 0.76-29.80 (38.2) | 5.35 (3.70) | 69.23 | 0.70-9.21 (12.1) | |
| 97013406 | 1.03 (0.19) | 18.48 | 0.73-1.29 (0.8) | 5.44 (8.40) | 154.55 | 0.81-23.70 (28.3) | 2.89 (1.75) | 60.55 | 0.39-5.25 (12.5) | |
| 98010075 | 1.11 (0.13) | 12.11 | 0.91-1.34 (0.5) | 7.72 (10.54) | 136.45 | 0.56-30.00 (52.6) | 4.83 (3.22) | 66.73 | 0.67-7.59 (10.3) | |
| A/H1N1 | 98010152 | 0.89 (1.36) | 151.87 | 0.27-4.94 (17.3) | 1.86 (0.86) | 45.98 | 0.76-3.20 (3.2) | 1.21 (0.63) | 51.67 | 0.21-1.92 (8.1) |
| 98013212 | 0.27 (0.04) | 15.24 | 0.22-0.34 (0.5) | 1.32 (0.74) | 56.01 | 0.39-2.49 (5.4) | 0.50 (0.27) | 53.46 | 0.16-0.74 (3.6) | |
| 98014203 | 0.26 (0.03) | 12.40 | 0.19-0.30 (0.6) | 1.91 (1.19) | 62.32 | 0.48-3.84 (7.0) | 1.40 (1.11) | 79.26 | 0.19-2.86 (14.1) | |
| 98026506 | 0.26 (0.07) | 25.40 | 0.17-0.41 (1.6) | 2.53 (1.64) | 64.94 | 0.60-5.74 (8.6) | 0.89 (0.48) | 54.45 | 0.13-1.35 (9.4) | |
| 98027803 | 0.45 (0.68) | 150.39 | 0.22-2.61 (10.9) | 5.15 (5.82) | 112.98 | 0.42-18.40 (42.8) | 0.81 (0.53) | 65.52 | 0.11-1.32 (11.0) | |
| A/H3N2 | 97011746 | 1.63 (0.68) | 41.41 | 0.22-2.24 (9.0) | 3.96 (4.77) | 120.47 | 1.21-14.40 (10.9) | 2.96 (1.88) | 63.44 | 0.50-4.29 (7.4) |
| 97011803 | 1.70 (0.72) | 42.40 | 0.26-2.36 (8.1) | 2.88 (1.72) | 59.67 | 1.03-6.56 (5.4) | 2.55 (1.67) | 65.65 | 0.37-4.03 (9.9) | |
| 97012203 | 1.82 (0.43) | 23.53 | 1.21-2.90 (1.4) | 5.26 (6.47) | 123.08 | 1.06-18.80 (16.7) | 2.93 (2.06) | 70.19 | 0.35-5.41 (60.2) | |
| 98010134 | 1.63 (0.27) | 16.64 | 1.29-2.07 (0.6) | 6.08 (7.75) | 127.54 | 0.85-21.40 (24.2) | 1.86 (1.23) | 66.22 | 0.32-3.15 (8.8) | |
| 98026522 | 2.07 (0.92) | 44.25 | 1.54-4.94 (2.2) | 13.11 (14.02) | 106.98 | 1.77-43.80 (23.7) | 6.22 (4.40) | 70.69 | 0.89-11.00 (11.4) | |
a
Ranges are given as minimum to maximum.