TABLE 3.
Oseltamivir carboxylate (GS4071) IC50 values for each clinical isolate in three NI assays
| Influenza virus type | Isolate | IC50 (nM) in the following assay:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CL assay (n = 12)
|
FA-1 (n = 12)
|
FA-2 (n = 6)
|
||||||||
| Mean (SD) | CV | Rangea (fold change) | Mean (SD) | CV | Rangea (fold change) | Mean (SD) | CV | Rangea (fold change) | ||
| B | 97012351 | 3.99 (0.85) | 21.34 | 2.89-5.80 (1.0) | 13.29 (4.52) | 33.99 | 7.85-26.00 (2.4) | 67.88 (22.74) | 33.49 | 43.60-107.00 (1.5) |
| 97012942 | 3.63 (0.73) | 20.07 | 2.86-5.57 (0.9) | 13.05 (1.85) | 14.20 | 9.81-15.70 (0.6) | 65.75 (19.01) | 28.92 | 44.40-96.80 (1.2) | |
| 97013118 | 4.81 (1.75) | 36.45 | 2.99-9.35 (2.1) | 12.81 (3.34) | 26.11 | 7.24-19.70 (1.7) | 71.05 (23.02) | 32.40 | 45.90-114.00 (1.5) | |
| 97013406 | 5.32 (2.46) | 46.26 | 0.54-8.75 (15.2) | 23.23 (9.74) | 41.92 | 0.37-36.20 (96.8) | 88.87 (12.48) | 14.04 | 68.10-104.00 (0.5) | |
| 98010075 | 3.58 (0.59) | 16.49 | 2.55-4.53 (0.8) | 13.55 (4.20) | 30.98 | 8.49-22.40 (1.6) | 64.32 (19.98) | 31.07 | 41.00-94.90 (1.3) | |
| A/H1N1 | 98010152 | 0.48 (0.17) | 35.06 | 0.36-0.98 (1.7) | 2.16 (1.33) | 61.76 | 0.66-4.26 (5.4) | 3.56 (1.06) | 29.75 | 2.04-4.71 (1.3) |
| 98013212 | 0.47 (0.13) | 28.46 | 0.37-0.82 (1.2) | 2.82 (4.14) | 146.85 | 0.45-14.60 (31.4) | 3.42 (0.81) | 23.74 | 2.19-4.17 (0.9) | |
| 98014203 | 0.47 (0.09) | 19.35 | 0.36-0.64 (0.8) | 2.19 (1.02) | 46.67 | 1.11-4.41 (3.0) | 6.78 (5.79) | 85.47 | 1.96-16.90 (7.6) | |
| 98026506 | 0.43 (0.10) | 22.81 | 0.29-0.65 (1.2) | 4.68 (6.77) | 144.60 | 0.93-24.50 (25.3) | 3.70 (1.44) | 38.80 | 1.38-5.27 (2.8) | |
| 98027803 | 0.40 (0.29) | 73.91 | 0.01-1.05 (104) | 5.31 (6.65) | 125.21 | 1.73-25.30 (13.6) | 2.79 (1.43) | 51.24 | 0.81-5.21 (5.4) | |
| A/H3N2 | 97011746 | 0.54 (0.16) | 29.37 | 0.32-0.90 (1.8) | 0.84 (0.54) | 63.88 | 0.33-1.90 (4.8) | 1.77 (0.30) | 17.02 | 1.41-2.13 (0.5) |
| 97011803 | 0.52 (0.14) | 26.64 | 0.41-0.94 (1.3) | 0.78 (0.30) | 38.29 | 0.37-1.19 (2.2) | 1.60 (0.25) | 15.90 | 1.25-1.85 (0.5) | |
| 97012203 | 0.37 (0.07) | 18.21 | 0.25-0.53 (1.1) | 0.92 (1.04) | 112.21 | 0.20-3.13 (14.7) | 0.96 (0.13) | 13.89 | 0.75-1.11 (0.5) | |
| 98010134 | 0.41 (0.03) | 7.55 | 0.37-0.48 (0.3) | 0.44 (0.18) | 40.86 | 0.07-0.72 (9.3) | 1.05 (0.20) | 19.02 | 0.77-1.25 (0.6) | |
| 98026522 | 0.30 (0.10) | 32.96 | 0.22-0.59 (1.7) | 0.23 (0.24) | 103.75 | 0.07-0.94 (12.4) | 0.75 (0.16) | 21.81 | 0.59-0.99 (0.7) | |
a
Ranges are given as minimum to maximum.