TABLE 1.
Susceptibilities of T. asahii isolates to fluconazole and voriconazole
| Patient no. (isolate no.) | MICa (mg/liter)
|
MFCb (mg/liter)
|
||
|---|---|---|---|---|
| Fluconazole | Voriconazole | Fluconazole | Voriconazole | |
| 1 (CBS 8973) | 16 (4) | 0.094 (0.125) | 32 | 0.50 |
| 2 (CBS 8975) | 32 (32) | 0.125 (0.125) | 128 | 0.25 |
| 3 (CBS 8969) | 24 (8) | 0.125 (0.125) | 64 | 0.25 |
| 4 (CBS 8971) | 24 (8) | 0.125 (0.25) | 64 | 1.00 |
| 5 (CBS 8970) | 24 (8) | 0.125 (0.125) | 64 | 0.50 |
| 6 (CBS 8972) | 32 (8) | 0.125 (0.125) | 64 | 0.25 |
| None (CBS 2479; type strain) | 24 (1) | 0.125 (0.25) | 64 | 0.25 |
a
MICs as determined by the Etest system (AB Biodisk). Within parentheses are the MICs determined according to the NCCLS microbroth dilution method (5), which were defined as the lowest drug concentration at which there was complete absence of growth (MIC-0).
b
The MFC was established as the lowest concentration of drug producing negative subcultures, after 20 μl of each clear well was plated on drug-free medium as described by Paphitou et al. (6).