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British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1982 Apr 10;284(6322):1081–1084. doi: 10.1136/bmj.284.6322.1081

Survival and desferrioxamine in thalassaemia major.

B Modell, E A Letsky, D M Flynn, R Peto, D J Weatherall
PMCID: PMC1497956  PMID: 6802413

Abstract

A small randomised trial and observation of all patients homozygous for beta-thalassaemia in Britain born in or before 1963 indicated that those patients who had received average weekly doses of more than 4 g of desferrioxamine over the previous few years were less likely to die in the near future than were patients of similar ages who had received less, or no, desferrioxamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry M., Flynn D. M., Letsky E. A., Risdon R. A. Long-term chelation therapy in thalassaemia major: effect on liver iron concentration, liver histology, and clinical progress. Br Med J. 1974 Apr 6;2(5909):16–20. doi: 10.1136/bmj.2.5909.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Henry W. L., Nienhuis A. W., Wiener M., Miller D. R., Canale V. C., Piomelli S. Echocardiographic abnormalities in patients with transfusion-dependent anemia and secondary myocardial iron deposition. Am J Med. 1978 Apr;64(4):547–555. doi: 10.1016/0002-9343(78)90572-7. [DOI] [PubMed] [Google Scholar]
  3. Hoffbrand A. V., Gorman A., Laulicht M., Garidi M., Economidou J., Georgipoulou P., Hussain M. A., Flynn D. M. Improvement in iron status and liver function in patients with transfusional iron overload with long-term subcutaneous desferrioxamine. Lancet. 1979 May 5;1(8123):947–949. doi: 10.1016/s0140-6736(79)91721-5. [DOI] [PubMed] [Google Scholar]
  4. Hussain M. A., Green N., Flynn D. M., Hussein S., Hoffbrand A. V. Subcutaneous infusion and intramuscular injection of desferrioxamine in patients with transfusional iron overload. Lancet. 1976 Dec 11;2(7998):1278–1280. doi: 10.1016/s0140-6736(76)92035-3. [DOI] [PubMed] [Google Scholar]
  5. Kaye S. B., Owen M. Cardiac arrhythmias in thalassaemia major: evaluation of chelation treatment using ambulatory monitoring. Br Med J. 1978 Feb 11;1(6109):342–342. doi: 10.1136/bmj.1.6109.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Letsky E. A. A controlled trial of long-term chelation therapy in homozygous beta-thalassemia. Birth Defects Orig Artic Ser. 1976;12(8):31–41. [PubMed] [Google Scholar]
  7. Modell B. Advances in the use of iron-chelating agents for the treatment of iron overload. Prog Hematol. 1979;11:267–312. [PubMed] [Google Scholar]
  8. Modell C. B., Beck J. Long-term desferrioxamine therapy in thalassemia. Ann N Y Acad Sci. 1974;232(0):201–210. doi: 10.1111/j.1749-6632.1974.tb20586.x. [DOI] [PubMed] [Google Scholar]
  9. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pippard M. J., Letsky E. A., Callender S. T., Weatherall D. J. Prevention of iron loading in transfusion-dependent thalassaemia. Lancet. 1978 Jun 3;1(8075):1178–1181. doi: 10.1016/s0140-6736(78)90968-6. [DOI] [PubMed] [Google Scholar]
  11. Propper R. D., Cooper B., Rufo R. R., Nienhuis A. W., Anderson W. F., Bunn H. F., Rosenthal A., Nathan D. G. Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med. 1977 Aug 25;297(8):418–423. doi: 10.1056/NEJM197708252970804. [DOI] [PubMed] [Google Scholar]
  12. Propper R. D., Shurin S. B., Nathan D. G. Reassessment of the use of desferrioxamine B in iron overload. N Engl J Med. 1976 Jun 24;294(26):1421–1423. doi: 10.1056/NEJM197606242942603. [DOI] [PubMed] [Google Scholar]
  13. SMITH R. S. CHELATING AGENTS IN THE DIAGNOSIS AND TREATMENT OF IRON OVERLOAD IN THALASSEMIA. Ann N Y Acad Sci. 1964 Oct 7;119:776–788. doi: 10.1111/j.1749-6632.1965.tb54079.x. [DOI] [PubMed] [Google Scholar]
  14. SMITH R. S. Iron excretion in thalassaemia major after administration of chelating agents. Br Med J. 1962 Dec 15;2(5319):1577–1580. doi: 10.1136/bmj.2.5319.1577. [DOI] [PMC free article] [PubMed] [Google Scholar]

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