Figure 2.

Adaptivity of the IL-2-binding surface. (a) Structure of the complex of IL-2 and Compound 1, shown as a surface representation of IL-2 (white and orange) and stick representation of Compound 1 (green). The residues that comprise the IL-2Rα-binding hot spot are shown in orange. Residues contacting the molecule are labeled. (b–d) Surface representation of three different unliganded structures (21) (b) and Native I and II (c and d; Table 1). Compound 1 is overlaid to emphasize the extent of rearrangement that occurs in both of the unliganded structures and in the liganded form. Movie 1 (RIGIMOL, W. L. DeLano) highlights the dynamic nature of this site across this series of structures.